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Aggressive orthotopic Kansas City Chiefs AFC West Champions Signatures Shirts glioblastoma enabled up to ~70% gene editing in vivo. So that which caused tumor cell apoptosis, inhibited tumor growth by 50%. And improved survival by 30%. To reach disseminated tumors, clips also engineered for antibody-targeted delivery. Intraperitoneal injections of EGFR-targeted sgPLK1-clips caused their selective uptake into disseminated ovarian tumors, enabled up to ~80% gene editing in vivo, inhibited tumor growth, and increased survival by 80%. The ability to disrupt gene expression in vivo in tumors opens new avenues for cancer treatment and research and potential applications for targeted gene editing of noncancerous tissues.
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